Trafficking of Immune Cells in the Cornea and Ocular Surface

The role of immuno-inflammatory responses in the cornea and ocular surface has continuously been evolving over the past decades and has been becoming the center stage for therapeutic approaches for many diseases. In fact, the relevance of inflammation as a significant component in the pathophysiology of most acute and chronic forms of corneal and ocular surface diseases (e.g., microbial keratitis, allergy, and dry eye syndrome) has become evident. Both local and systemic immunomodulation with anti-inflammatory agents have been used successfully in improving these conditions or bringing these conditions under control. Thus, understanding the cellular and molecular mechanisms by which the ocular surface participates in immuno-inflammatory disorders is crucial for a more rational clinical approach to treating these diseases.